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Journal article 40 Citations

Hepatic cellular immune responses in mice with ⿿cure⿝ and ⿿non-cure⿝ phenotype toLeishmania infantuminfection: importance of CD8+T cells and TGF-β production

Sandra Gomes-Pereira , Olivia Roos Rodrigues , Nuno Rolão , Paulo David Almeida , Gabriela Maria Santos-Gomes
ISLA — Instituto Politécnico de Gestão e Tecnologia
FEMS Immunology & Medical Microbiology, Volume 41, Issue 1, 05 2004, pp. 59–68
DOI: 10.1016/j.femsim.2004.01.003

Resume

Abstract
The objective of this study was to analyse hepatic cellular immune response of mice with "cure" and "non-cure" phenotypes to Leishmania infantum infection. During infection establishment, elevated TGF-beta levels and absence of a Th1 response may have contributed to parasite multiplication and to similar hepatic parasitic loads. Later in infection, an increase in the number and activation levels of CD8+ cells was observed simultaneously with parasite elimination, but only significant in "cure" strain. During this recovering phase, "non-cure" animals showed low Th2 cytokine levels, while TGF-beta production was higher than in "cure" mice. These results point out to a role for CD8+ T cells in liver acquired immune response and to TGF-beta regulation of "cure" and "non-cure" phenotype to L. infantum infection.

Keywords

#Leishmania infantum #visceral leishmaniasis #CD8+ T cells #TGF-beta #Th1 response #Th2 cytokines #parasite clearance #liver infection #Immune system #Biology #CD8 #Immunology #Leishmania #Phenotype

Bibliographic Details

Publication Type Journal article
Publication Year 2004
Journal / Conference / Work FEMS Immunology & Medical Microbiology
ISSN 0928-8244
Volume / Issue Vol. 41 (1)
Pagination pp. 59–68

ISLA Authors & Affiliations

S
Sandra Isabel Gomes Pereira
sandra.pereira@islagaia.pt ID: 511C-D166-B855
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