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Journal article Open Access Scopus Source The journal / series is indexed in Scopus (SCImago list). The article itself has not been verified. 9 Citations Quartil Q2

Genitourinary changes in hamsters infected and reinfected with Trypanosoma cruzi

Cabrine-Santos, M , dos Santos, VM , de Lima, MA , de Abreu, MEA , Lages-Silva, E , Ramirez, LE
ISLA — Instituto Politécnico de Gestão e Tecnologia
Memorias do Instituto Oswaldo Cruz, 2003
DOI: 10.1590/S0074-02762003000400018

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Abstract
Authors describe genitourinary changes in male hamsters infected and reinfected with Trypanosoma cruzi. Changes in genital organs have been described in human and in experimental chagasic infection. Genital dysfunctions in chronic chagasic patients affect ejaculation, libido and sexual potency, and testis biopsies may show arrested maturation of germ cells, oligozoospermia and azoospermia. Sixty-five male hamsters were inoculated and reinoculated with 2x10 trypomastigotes of T. cruzi VIC strain, and 22 non-infected animals constituted the control group. Animals were necropsied and fragments from testis, epididymis, seminal vesicle and bladder were collected and stained with hematoxylin-eosin. Peroxidase anti-peroxidase procedure was utilized to detect tissue parasitism. T. cruzi nests were found in testis, epididymis and seminal vesicle of these hamsters. Such parasitism plays a role in the origin of genital lesions observed in humans and laboratory animals during chronic chagasic infection.

Keywords

#Trypanosoma cruzi #Chagas disease #male hamsters #reinfection #testis #epididymis #seminal vesicle #urinary bladder #germ cell maturation #azoospermia #oligozoospermia #sexual dysfunction #tissue parasitism #Biology #Vas deferens #Ejaculatory duct #Andrology #Genitourinary system

Bibliographic Details

Publication Type Journal article
Publication Year 2003
Journal / Conference / Work Memorias do Instituto Oswaldo Cruz
Quartile (SCImago) Q2
Scopus Indexing Indexed source (via SCImago)

ISLA Authors & Affiliations

M
Maria Madalena Eça Guimarães de Abreu
mabreu@iscac.pt ID: 811A-E805-4D69
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